Endocrine Abstracts

For the diagnosis of hyperinsulinemic hypoglycemia (HH), it is necessary that in symptomatic hypoglycemia in the fasting test the insulin/glucose ratio is >0.3, or that in spontaneous hypoglycemia there are C-peptide >0.6 nmol/l and insulin >3.0 mIU/ml. It is a well-known fact about the increasing frequency of hypoglycemia after bariatric surgery (estimated up to 30% of patients), mostly within the Dumping syndrome, but the frequency of occurrence of noninsulinoma ...

Transition from childhood to adulthood is a vulnerable period in all adolescents and particularly inCO-GHD patients. Low bone mineral density (BMD) and body composition alterations are frequently reported in young adults with CO-GHD, but relevant large monocentric studies are lacking.Patients and Methods: In a monocentric, observational, retrospective cross-sectional study conducted from 2005–2019, 107 CO-GHD patients were analyzed (17–26 yea...

Introduction: Hashimoto thyroiditis (HT), chronic autoimmune disease, is related with impaired quality of life (QoL) regardless of euthyroid state. Some studies showed decreased levels of vitamin D in patients with HT which implies there is a relationship between vitamin D deficiency and HT. It remains unclear whether decreased levels of vitamin D are result of autoimmune process or are part of its cause.Aim: To investigate effect of vitamin D levels on ...

Introduction: The aim of the study was to establish the predictive factors for endocrine disease-induced hyponatremia.Patients and methods: Fifty-two patients with hyponatremia (Na <135 nmol/l) were referred to Department of Neuroendocrinology, University Clinical Center of Serbia from January 2015 to March 2023 (n=52; 31 females, 60%) mean age 60.5&pm;14.1 years, mean serum sodium level 124.9&pm;9.0 mmol/l. Seven patients (13.4%) with trans...

Background: Increased life expectancy and wider availability of neuroimaging lead to increase in diagnosis of acromegaly in elderly patients, after the age of 70. Delay in diagnosis is attributable to milder symptomatology, higher prevalence of comorbidities and symptoms overlapping with normal aging process.Objective: To investigate clinical characteristics, presenting symptoms, comorbidities and treatment modalities of acromegaly in patients diagnosed ...

Background: A subset of patients with prolactinomas does not respond satisfactorily to first-line medical therapy with dopamine agonists (DA). DA resistance is defined as failure to normalize prolactin (PRL) levels and/or to achieve ≥50% reduction in maximal tumor diameter under maximally tolerated doses (or a weekly cabergoline dose of ≥3mg). The predictive factors for DA resistance are male gender and tumor invasiveness.Aim: To characterize...

Introduction: Considering the mitogenic potential of GH and IGF1, the safety profile of growth hormone therapy since the beginning of its use has been debated. From that point of view, adolescents in transition to adulthood who were treated in childhood for endocranial tumors or malignancies require special caution.Patients and Methods: In a monocentric, observational, retrospective cross-sectional study spanning 18 years, we analyzed 251 childhood onset...